Emodin
| CAS No. | 518-82-1 | Cat. No. | BCP18372 |
| Name | Emodin | ||
| Synonyms | Emodol;Frangula emodin; | ||
| Formula | C15H10O5 | M. Wt | 270.24 |
| Description | Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. Purified emodin has diverse effects, including the suppression of inflammation, dyslipidemia, and cancer. At a molecular level, emodin directly and selectively inhibits casein kinase II (IC50 = 0.89 μM). Through this action, it inhibits the COP9 signalosome, causing the stabilization of the tumor suppressor p53. Moreover, emodin acts as a phytoestrogen, binding human estrogen receptors and blocking 17β-estradiol binding with Ki values of 0.77 and 1.5 μM for ERα and ERβ, respectively. | ||
| Pathways | Cell Cycle/DNA Damage Wnt/Stem Cell | ||
| Targets | Casein Kinase | ||
Structure
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