SIS3 HCl
| CAS No. | 521984-48-5 | Cat. No. | BCP19304 |
| Name | SIS3 HCl | ||
| Synonyms | SIS-3;SIS 3; | ||
| Formula | C28H28ClN3O3 | M. Wt | 489.99 |
| Description | SIS3 Reduces the TGF-β1-Dependent Increase in Phosphorylation and DNA Binding of Smad3. SIS3 has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. SIS3 can block excessive ECM production from the TGF-β1-treated normal fibroblasts and scleroderma fibroblasts, the model of cells with autocrine TGF-β signaling in vitro. | ||
| Pathways | TGF beta/Smad Wnt/Stem Cell | ||
| Targets | TGF β/Smad | ||
Structure
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