4SC-202 tosylate

CAS No.	1186222-89-8	Cat. No.	BCP25159
Name	4SC-202 tosylate
Synonyms	4SC202 tosylate；4SC 202 tosylate；Domatinostat tosylate;
Formula	C30H29N5O6S2	M. Wt	619.71

Description	4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins.
Pathways	Cell Cycle/DNA Damage Epigenetics
Targets	HDAC

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