Tyrphostin AG 555
| CAS No. | 133550-34-2 | Cat. No. | BCP25507 |
| Name | Tyrphostin AG 555 | ||
| Synonyms | Tyrphostin B-46;Tyrphostin B46;AG555; AG 555; AG-555; | ||
| Formula | C19H18N2O3 | M. Wt | 322.36 |
| Description | AG 555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G1 growth arrest selectively in transformed cells (IC50 values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively). | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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