Sitravatinib
| CAS No. | 1123837-84-2 | Cat. No. | BCP29099 |
| Name | Sitravatinib | ||
| Synonyms | MGCD516; MGCD-516; MGCD 516; MG516; MG 516; MG-516; | ||
| Formula | C33H29F2N5O4S | M. Wt | 629.68 |
| Description | Sitravatinib, also known as MGCD516 or MG516, is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. MGCD516 treatment resulted in significant blockade of phosphorylation of potential driver RTKs and induced potent anti-proliferative effects in vitro. MGCD516 treatment of tumor xenografts in vivo resulted in significant suppression of tumor growth. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | TAM Receptor PDGFR c Met c Kit DDR | ||
Structure
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