BIBN 4096BS
| CAS号 | 204697-65-4 | 货号 | BCP29403 |
| 中文名 | BIBN 4096BS | ||
| 英文名 | BIBN 4096BS | ||
| 中文别名 | |||
| 英文别名 | BIBN-4096; BIBN4096; BIBN 4096; BIBN-4096BS; BIBN4096BS; Olcegepant; | ||
| 分子式 | C38H47Br2N9O5 | 分子量 | 869.65 |
| 生物活性 | BIBN 4096BS, also known as BIBN-4096 or Olcegepant is is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor, a key modulator in neurogenic inflammatory pain. In preclinical studies, olcegepant attenuated arterial dilation induced by CGRP or electrical stimulation. In a phase II clinical trial, olcegepant reduced the severity of headache in 60% of migraine sufferers and met secondary endpoints including headache-free rate and rate of sustained response. The compound appears to be an effective anti-migraine medication that is well tolerated and does not display the vasoconstrictive effect that precludes the use of triptans and dihydroergotamine in certain patients. | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | CGRP Receptor | ||
结构式
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