Mobocertinib succinate

  • Chemical Properties
CAS No. 2389149-74-8 Cat. No. BCP33315
Name Mobocertinib succinate
Synonyms TAK-788 succinate; AP32788 succinate;TAK 788 succinate; AP 32788 succinate;TAK788 succinate; AP-32788 succinate;
Formula C36H45N7O8 M. Wt 703.78
  • Biological Activity
Description Mobocertinib succinate is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity.Mobocertinib, also known as TAK-788 and AP32788, is an investigational TKI with potent, selective preclinical activity against activating EGFR and HER2 mutations, including exon 20 insertions. TAK-788 exhibits antitumor activity in pts with EGFR exon 20 insertions with an AE profile consistent with other EGFR TKIs.
Pathways Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway 
Targets EGFR HER2 

Structure

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