LMP744
| CAS No. | 308246-52-8 | Cat. No. | BCP34017 |
| Name | LMP744 | ||
| Synonyms | LMP-744; LMP 744; MJ-III-65; MJ-III65; NSC-706744;NSC 706744; NSC706744; | ||
| Formula | C24H24N2O7 | M. Wt | 452.46 |
| Description | LMP744 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP744 produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP744 at nanomolar concentrations. Studies in human cells in culture found LMP744 to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP744 also exhibits antitumor activity in mouse tumor xenografts. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
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