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LMP744 Chemical Structure

LMP744

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP34017CAS No. ：308246-52-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 308246-52-8 Cat. No. BCP34017
Name LMP744
Synonyms LMP-744; LMP 744; MJ-III-65; MJ-III65; NSC-706744;NSC 706744; NSC706744;
SMILES COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCNCCO)OC
Chemical Name
Formula C24H24N2O7 M. Wt 452.46
Purity 98% Storage Store at 4-8°C
Description LMP744 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP744 produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP744 at nanomolar concentrations. Studies in human cells in culture found LMP744 to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP744 also exhibits antitumor activity in mouse tumor xenografts.
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