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Chimmitecan Chemical Structure

Chimmitecan

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP40436CAS No. ：185425-25-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 185425-25-6 Cat. No. BCP40436
Name Chimmitecan
Synonyms (S)-9-Allyl-10-hydroxycamptothecin;9-Allyl-10-Hydroxycamptothecin;
SMILES CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CC=C)O)N=C4C3=C2)O
Chemical Name
Formula C23H20N2O5 M. Wt 404.42
Purity 98% Storage Store at 4-8°C
Description Chimmitecan is a potent topoisomerase I inhibitor. Chimmitecan is also an active metabolite of simmitecan. Chimmitecan displays outstanding activity in vitro and in vivo. The substitution at the 9-position benefits chimmitecan a salient anti-MDR activity, stability in human serum albumin, improved solubility, and oral availability, which might favorably promise its therapeutic potential in clinical settings.
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