Chimmitecan
| CAS No. | 185425-25-6 | Cat. No. | BCP40436 |
| Name | Chimmitecan | ||
| Synonyms | (S)-9-Allyl-10-hydroxycamptothecin;9-Allyl-10-Hydroxycamptothecin; | ||
| Formula | C23H20N2O5 | M. Wt | 404.42 |
| Description | Chimmitecan is a potent topoisomerase I inhibitor. Chimmitecan is also an active metabolite of simmitecan. Chimmitecan displays outstanding activity in vitro and in vivo. The substitution at the 9-position benefits chimmitecan a salient anti-MDR activity, stability in human serum albumin, improved solubility, and oral availability, which might favorably promise its therapeutic potential in clinical settings. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
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