ALX 40-4C
| CAS No. | 143413-49-4 | Cat. No. | BCP34188 |
| Name | ALX 40-4C | ||
| Synonyms | ALX-40-4C;ALX40-4C;Ac-(D-Arg)9-NH2;N-alpha-Acetyl-nona-D-arginine amide acetate; | ||
| Formula | C56H113N37O10 | M. Wt | 1464.74 |
| Description | ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, interacts with the second extracellular loop of CXCR4 and inhibits infection exclusively by blocking direct virus-CXCR4 interactions. ALX 40-4C shows potent anti HIV-1 effect, with EC50s of 0.34 ± 0.04 μg/mL, 0.37 ± 0.01 μg/mL for HIV-1 NL4-3, NC10, and 0.18 ± 0.11 μg/mL, 0.06 ± 0.02 μg/mL for HIV-1 HXB2, HC43, respectively, and with a CC50 (50% cytotoxic concentration) of 21 μg/mL. | ||
| Pathways | GPCR/G Protein | ||
| Targets | CXCR | ||
Structure
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