Zandelisib
CAS No. | 1401436-95-0 | Cat. No. | BCP36800 |
Name | Zandelisib | ||
Synonyms | PWT143; PWT-143; PWT 143; ME-401; ME401; ME 401; | ||
Formula | C31H38F2N8O | M. Wt | 576.68 |
Description | Zandelisib, also known as PWT143 and ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, PI3K-delta inhibitor PWT143 selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. | ||
Pathways | PI3K/Akt/mTOR | ||
Targets | PI3K |
Structure
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