Zandelisib

  • Chemical Properties
CAS No. 1401436-95-0 Cat. No. BCP36800
Name Zandelisib
Synonyms PWT143; PWT-143; PWT 143; ME-401; ME401; ME 401;
Formula C31H38F2N8O M. Wt 576.68
  • Biological Activity
Description Zandelisib, also known as PWT143 and ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, PI3K-delta inhibitor PWT143 selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
Pathways PI3K/Akt/mTOR 
Targets PI3K 

Structure

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