Zandelisib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP36800CAS No. ：1401436-95-0Purity：98%

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CAS No.	1401436-95-0	Cat. No.	BCP36800
Name	Zandelisib
Synonyms	PWT143; PWT-143; PWT 143; ME-401; ME401; ME 401;
SMILES	CC(C)(CC1=CC=CC=C1C2CCN(CC2)C)NC3=NC(=NC(=N3)N4CCOCC4)N5C6=CC=CC=C6N=C5C(F)F
Chemical Name
Formula	C31H38F2N8O	M. Wt	576.68
Purity	98%	Storage	Store at 4-8°C
Description	Zandelisib, also known as PWT143 and ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, PI3K-delta inhibitor PWT143 selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.