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Panulisib Chemical Structure

Panulisib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP44105CAS No. :1356033-60-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1356033-60-7 Cat. No. BCP44105
Name Panulisib
Synonyms AK151761; AK 151761; AK-151761; P7170; P 7170; P-7170;
SMILES CC(C)(C#N)C1=NC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=NC#N)C)C5=CC(=C(N=C5)N)C(F)(F)F
Chemical Name
Formula C27H20F3N9 M. Wt 527.5
Purity 98% Storage Store at 4-8°C
Description Panulisib is a small molecule inhibitor of PI3K (IC50 = 2.2 nM) and mTOR (IC50 = 4.4 nM). It also inhibits ALK1 and DNA-PK, two important enzymes involved in angiogenesis and DNA repair with IC50 of 47 and 1.5 nM, respectively. P7170 inhibited PI3K-mTOR pathway proteins pAKT, pS6 and p4EBP1 by 90 to 100 % in Kras mutated NSCLC cell line (H460) in a western blot assay. P7170 also exhibited potent cytotoxicity activity against two Kras mutated NSCLC (H460 and A549) cell lines with IC50 values of 7 and 5 nM. P7170 by virtue of its unique profile represents an opportunity to deliver a first-in-class therapeutic option for patients saddled with Kras mutated non small cell lung cancer.
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