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SAR405 R enantiomer Chemical Structure

SAR405 R enantiomer

Data Sheet For research use only. Not for human use.
Cat. No. :BCP37991CAS No. :1946010-79-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1946010-79-2 Cat. No. BCP37991
Name SAR405 R enantiomer
Synonyms SAR-405 R enantiomer;SAR 405 R enantiomer;
SMILES CC1COCCN1C2=CC(=O)N3CCC(N(C3=N2)CC4=CC(=CN=C4)Cl)C(F)(F)F
Chemical Name
Formula C19H21ClF3N5O2 M. Wt 443.85
Purity 98% Storage Store at 4-8°C
Description SAR405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
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