Umbralisib tosylate New
Data Sheet
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| CAS No. | 1532533-72-4 | Cat. No. | BCP24684 |
| Name | Umbralisib tosylate | ||
| Synonyms | TGR-1202 tosylate; RP5264 tosylate;TGR-1202 (4-methylbenzenesulfonate); | ||
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)OC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)C4=C(C(=O)C5=C(O4)C=CC(=C5)F)C6=CC(=CC=C6)F)F | ||
| Chemical Name | |||
| Formula | C38H32F3N5O6S | M. Wt | 743.75 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Umbralisib Tosylate is the tosylate form of umbralisib, an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. umbralisib inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. | ||
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