SAR405 R enantiomer

  • Chemical Properties
CAS No. 1946010-79-2 Cat. No. BCP37991
Name SAR405 R enantiomer
Synonyms SAR-405 R enantiomer;SAR 405 R enantiomer;
Formula C19H21ClF3N5O2 M. Wt 443.85
  • Biological Activity
Description SAR405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
Pathways PI3K/Akt/mTOR 
Targets PI3K 

Structure

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