JND3229
| CAS No. | 2260886-64-2 | Cat. No. | BCP38649 |
| Name | JND3229 | ||
| Synonyms | JND-3229;JND 3229; | ||
| Formula | C33H41ClN8O2 | M. Wt | 617.18 |
| Description | JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM). JND3229 potently inhibited EGFRC797S mutated kinase and strongly suppressed the proliferation of BaF3 cells harboring the EGFRL858R/T790M/C797S and EGFR19D/T790M/C797S mutations with IC50 values of 0.51 and 0.32 μM, respectively. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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