Pracinostat Dihydrochloride

  • Chemical Properties
CAS No. 929016-98-8 Cat. No. BCP43352
Name Pracinostat Dihydrochloride
Synonyms Pracinostat 2HCl; Fezolinetant; ESN-364; ESN 364; ESN364;
Formula C20H32Cl2N4O2 M. Wt 431.4
  • Biological Activity
Description Pracinostat, also known as SB939, is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis.
Pathways Cell Cycle/DNA Damage Epigenetics 
Targets HDAC 

Structure

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