DC-Cholesterol HCl
CAS No. | 166023-21-8 | Cat. No. | BCP44901 |
Name | DC-Cholesterol HCl | ||
Synonyms | DC Cholesterol; | ||
Formula | C32H56N2O2.HCl | M. Wt | 537.26 |
Description | DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with DOPE, has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice. | ||
Pathways | Cell Cycle/DNA Damage | ||
Targets | DNA/RNA Synthesis |
Structure
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