TH5427
| CAS No. | 2253744-56-6 | Cat. No. | BCP46030 |
| Name | TH5427 | ||
| Synonyms | TH-5427;TH 5427; | ||
| Formula | C20H20Cl2N8O3 | M. Wt | 491.33 |
| Description | TH5427 is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis | ||
Structure
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