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TH5427 Chemical Structure

TH5427

Data Sheet For research use only. Not for human use.
Cat. No. :BCP46030CAS No. :2253744-56-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2253744-56-6 Cat. No. BCP46030
Name TH5427
Synonyms TH-5427;TH 5427;
SMILES CC1=CC(=CC=C1)C2=NN=C(O2)CN3C4=C(N=C3N(C)C)N(C(=O)N(C4=O)C)C
Chemical Name
Formula C20H20Cl2N8O3 M. Wt 491.33
Purity 98% Storage Store at 4-8°C
Description TH5427 is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.
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