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CAS No. | 2253744-56-6 | Cat. No. | BCP46030 |
Name | TH5427 | ||
Synonyms | TH-5427;TH 5427; | ||
SMILES | CC1=CC(=CC=C1)C2=NN=C(O2)CN3C4=C(N=C3N(C)C)N(C(=O)N(C4=O)C)C | ||
Chemical Name | |||
Formula | C20H20Cl2N8O3 | M. Wt | 491.33 |
Purity | 98% | Storage | Store at 4-8°C |
Description | TH5427 is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. |
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