JH-RE-06 New
Data Sheet
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| CAS No. | 1361227-90-8 | Cat. No. | BCP48872 |
| Name | JH-RE-06 | ||
| Synonyms | JH-RE06; JH-RE 06; JHRE-06; JHRE06; JHRE 06; | ||
| SMILES | ClC1=C(NC(NC2=CC=C(Cl)C=C2Cl)=C(C(CC(C)C)=O)C3=O)C3=C([N+]([O-])=O)C=C1 | ||
| Chemical Name | |||
| Formula | C20H16Cl3N3O4 | M. Wt | 468.72 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | JH-RE-06 is a potent REV1 inhibitor. JH-RE-06 disrupts mutagenic TLS by preventing recruitment of mutagenic POL ζ. JH-RE-06 targets a nearly featureless surface of REV1 that interacts with the REV7 subunit of POL ζ. JH-RE-06 inhibits mutagenic TLS and enhances cisplatin-induced toxicity in cultured human and mouse cell lines. Co-administration of JH-RE-06 with cisplatin suppresses the growth of xenograft human melanomas in mice, establishing a framework for developing TLS inhibitors as a novel class of chemotherapy adjuvants. | ||
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