SKLB-197
| CAS No. | 2713577-16-1 | Cat. No. | BCP46440 |
| Name | SKLB-197 | ||
| Synonyms | SKLB 197; SKLB197; | ||
| Formula | C25H24N6O | M. Wt | 424.51 |
| Description | SKLB-197 is a potent and highly selective ATR inhibitor. SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo. In addition, this compound exhibited good pharmacokinetic properties. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | ATM/ATR | ||
Structure
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