SKLB-197 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2713577-16-1 | Cat. No. | BCP46440 |
| Name | SKLB-197 | ||
| Synonyms | SKLB 197; SKLB197; | ||
| SMILES | CC1COCCN1C2=NC(=NC3=C2C=C(C=C3)C4=CC=NN4C)C5=C6C=CNC6=CC=C5 | ||
| Chemical Name | |||
| Formula | C25H24N6O | M. Wt | 424.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SKLB-197 is a potent and highly selective ATR inhibitor. SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo. In addition, this compound exhibited good pharmacokinetic properties. | ||
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