Bmh-21
Data Sheet
For research use only. Not for human use.
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| CAS No. | 896705-16-1 | Cat. No. | BCP13273 |
| Name | Bmh-21 | ||
| Synonyms | Bmh 21;Bmh21; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H20N4O2 | M. Wt | 360.16 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. BMH-21 does not cause phosphorylation of H2AX, a key biomarker activated in DNA damage stress. BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress. The findings also show that interference with DNA and DNA metabolic processes can be exploited therapeutically without causing DNA damage. | ||
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