Camonsertib New
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| CAS No. | 2417489-10-0 | Cat. No. | BCP46512 |
| Name | Camonsertib | ||
| Synonyms | RP 3500; RP-3500; RP3500;ATR inhibitor 4; | ||
| SMILES | O[C@@]1(C2=C3C(N(C4=NNC=C4)N=C3)=NC(N5[C@H](C)COCC5)=C2)C[C@@](O6)([H])CC[C@@]6([H])C1 | ||
| Chemical Name | |||
| Formula | C21H26N6O3 | M. Wt | 410.48 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Camonsertib, also known as RP 3500, is aA Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors. RP-3500 is highly potent with IC50 values of 1.0 and 0.33 nmol/L in biochemical and cell-based assays, respectively. RP-3500 is highly selective for ATR with 30-fold selectivity over mammalian target of rapamycin (mTOR) and more than 2,000-fold selectivity over ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase (DNA-PK), and phosphatidylinositol 3-kinase alpha (PI3Kα) kinases. | ||
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