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NU 6027 Chemical Structure

NU 6027

Data Sheet For research use only. Not for human use.
Cat. No. :BCP09221CAS No. :220036-08-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 220036-08-8 Cat. No. BCP09221
Name NU 6027
Synonyms NU-6027;NU6027;
SMILES
Chemical Name
Formula C11H17N5O2 M. Wt 251.29
Purity 98% Storage Store at 4-8°C
Description A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki = 2.5 μM for CDK1, and Ki = 1.3 μM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50 = 6.7 μM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 μM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells.
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