LY3143921 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP48019CAS No. ：1627696-52-9Purity：98%

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CAS No.	1627696-52-9	Cat. No.	BCP48019
Related Products	1627696-51-8（LY-3177833） 1627696-53-0（LY3143921 hydrate）
Name	LY3143921
Synonyms	LY-3143921;LY 3143921;(S)-LY3177833;
SMILES	CC1(C2=C(C=C(C=C2)C3=CNN=C3)C(=O)N1)C4=NC=NC=C4F
Chemical Name
Formula	C16H12FN5O	M. Wt	309.3
Purity	98%	Storage	Store at 4-8°C
Description	LY3143921 is a potent and selective CDC7 kinase inhibitor. LY3143921 targets, binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 plays a key role in DNA replication by binding to and phosphorylating serine (Ser)-40 and 53 of MCM2 (minichromosome maintenance complex component 2), which is required for the initiation of DNA replication. Although expressed at low levels in healthy, normal cells, CDC7 is expressed at much higher levels in cancer cells.