CDK12-IN-2 New
Data Sheet
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| CAS No. | 2244987-03-7 | Cat. No. | BCP46385 |
| Name | CDK12-IN-2 | ||
| Synonyms | CDK12 inhibitor 2; | ||
| SMILES | CN1C=C(C=CC1=O)C2=CC=C(C=C2)N(C3CCC(CC3)NC4=NC=C(C=C4)C#N)C(=O)NCC5=CC=CC=C5 | ||
| Chemical Name | |||
| Formula | C32H32N6O2 | M. Wt | 532.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12. | ||
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