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AZ32 Chemical Structure

AZ32

Data Sheet For research use only. Not for human use.
Cat. No. :BCP29590CAS No. :AZ32Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. AZ32 Cat. No. BCP29590
Name AZ32
Synonyms AZ 32;AZ-32;
SMILES O=C(NC)C(C=C1)=CC=C1C2=CN=C3C=NC(C4=CC=CC=C4)=CN32
Chemical Name
Formula C20H16N4O M. Wt 328.37
Purity 98% Storage Store at 4-8°C
Description AZ32 is an orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) that radiosensitizes intracranial gliomas in mice. AZ32 was highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models.
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