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ATM Inhibitor-5 Chemical Structure

ATM Inhibitor-5

Data Sheet For research use only. Not for human use.
Cat. No. :BCP47340CAS No. :2020089-41-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2020089-41-0 Cat. No. BCP47340
Name ATM Inhibitor-5
Synonyms M4076;M 4076;M-4076;
SMILES CC1=NN(C=C1C2=C(C=C3C(=C2)C4=C(C=N3)N(C(=O)N4C5=C(C=NC=C5OC)F)C)OC)C
Chemical Name
Formula C23H21FN6O3 M. Wt 448.45
Purity 98% Storage Store at 4-8°C
Description ATM Kinase Inhibitor M4076 is an orally bioavailable ATP-competitive inhibitor of ataxia telangiectasia mutated kinase (ATM), with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, M4076 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, by preventing DNA damage repair, M4076 sensitizes tumor cells to chemo- and radiotherapy and increases their anti-tumor activity. ATM, a serine/threonine protein kinase upregulated in a variety of cancer cell types, is activated in response to DNA damage and plays a key role in DNA-strand repair.
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