ME-344
| CAS No. | 1374524-68-1 | Cat. No. | BCP46464 |
| Name | ME-344 | ||
| Synonyms | ME 344; ME344; | ||
| Formula | C22H20O4 | M. Wt | 348.39 |
| Description | ME-344 is an active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation. Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells. In pre-clinical studies, ME-344 has shown tenfold more anti-tumor activity than NV-128. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | mTOR | ||
Structure
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