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ME-344 Chemical Structure

ME-344

Data Sheet For research use only. Not for human use.
Cat. No. :BCP46464CAS No. :1374524-68-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1374524-68-1 Cat. No. BCP46464
Name ME-344
Synonyms ME 344; ME344;
SMILES CC1=C(C=CC2=C1OCC(C2C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)O
Chemical Name
Formula C22H20O4 M. Wt 348.39
Purity 98% Storage Store at 4-8°C
Description ME-344 is an active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation. Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells. In pre-clinical studies, ME-344 has shown tenfold more anti-tumor activity than NV-128.
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