ONC-201 Dihydrochloride
| CAS号 | 1638178-82-1 | 货号 | BCP46830 |
| 中文名 | ONC-201 Dihydrochloride | ||
| 英文名 | ONC-201 Dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | ONC201 2HCl;ONC 201 2HCl;ONC-201 2HCl; | ||
| 分子式 | C24H28Cl2N4O | 分子量 | 459.42 |
| 生物活性 | ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL. | ||
| 上下游产品 | 1616632-77-9（ONC201） 41276-02-2（TIC10 Analogue） | ||
| 信号通路 | Apoptosis Pathway PI3K/Akt/mTOR MAPK Pathway | ||
| 靶 点 | TNF Receptor MEK/ERK AKT | ||
结构式
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