ONC-201 Dihydrochloride 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP46830CAS号：1638178-82-1纯度：98%

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CAS号	1638178-82-1	货号	BCP46830
关联产品	1616632-77-9（ONC201） 41276-02-2（TIC10 Analogue）
中文名	ONC-201 Dihydrochloride
英文名	ONC-201 Dihydrochloride
中文别名
英文别名	ONC201 2HCl;ONC 201 2HCl;ONC-201 2HCl;
SMILES	CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5.Cl.Cl
化学名称
分子式	C24H28Cl2N4O	分子量	459.42
纯度	98%	配送	惯例下常温包邮
产品描述	ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.