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ASN007 benzenesulfonate 结构式

ASN007 benzenesulfonate

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货号 :BCP48484CAS号 :2055597-39-0纯度:98%
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  • 基本信息与产品描述
CAS号 2055597-39-0 货号 BCP48484
关联产品 2055597-12-9(ASN007)
中文名 ASN007 benzenesulfonate
英文名 ASN007 benzenesulfonate
中文别名
英文别名 ASN-007 benzenesulfonate ;ASN 007 benzenesulfonate ;ERK-IN-3 benzenesulfonate;
SMILES
化学名称
分子式 C28H31ClFN7O5S 分子量 632.11
纯度 98% 配送 惯例下常温包邮
产品描述 ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. with low single-digit nM IC50 values. ASN007 showed a slow dissociation rate (long target residence time) as compared to several other known ERK inhibitors. In mechanistic cell-based assays, ASN007 inhibited the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showed single-digit nanomolar antiproliferative activity that was selective for MAPK-pathway dependent cancer cell lines.
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