硫酸司美替尼新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP36547CAS号：943332-08-9纯度：98%

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CAS号	943332-08-9	货号	BCP36547
中文名	硫酸司美替尼
英文名	Selumetinib sulfate
中文别名	AZD6244硫酸盐;硫酸司美替尼;
英文别名	AZD-6244 sulfate;AZD 6244 sulfate;AZD6244 sulfate; ARRY-142886 sulfate;
SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO.OS(=O)(=O)O
化学名称
分子式	C17H17BrClFN4O7S	分子量	555.76
纯度	98%	配送	惯例下常温包邮
产品描述	Selumetinib Sulfate is the sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers.

硫酸司美替尼 新