APS-2-79 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP24938CAS号：2002381-25-9纯度：98%

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CAS号	2002381-25-9	货号	BCP24938
中文名	APS-2-79
英文名	APS-2-79
中文别名
英文别名	APS 2-79; APS2-79; APS-279; APS 279; APS279;
SMILES	CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC
化学名称
分子式	C23H21N3O3	分子量	387.43
纯度	98%	配送	惯例下常温包邮
产品描述	APS-2-79 is a KSR-dependent MAPK modulator. APS-2-79 modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK (mitogen-activated protein kinase kinase). APS-2-79 increased the potency of several MEK inhibitors specifically within Ras-mutant cell lines by antagonizing release of negative feedback signalling, demonstrating the potential of targeting KSR to improve the efficacy of current MAPK inhibitors. Co-targeting of enzymatic and scaffolding activities within Ras-MAPK signalling complexes is a therapeutic strategy for overcoming Ras-driven cancers.