ABC99
| CAS No. | 2331255-53-7 | Cat. No. | BCP47152 |
| Name | ABC99 | ||
| Synonyms | ABC-99; ABC 99; | ||
| Formula | C22H21ClN4O5 | M. Wt | 456.88 |
| Description | ABC99 is a Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme, ABC99 inhibited NOTUM with an IC50 value of 13 nM and showed excellent selectivity across the serine hydrolase family, as initially assessed by gel-based ABPP of soluble and membrane proteomes from SW620 cells. ABC99 preserves Wnt-mediated cell signaling in the presence of NOTUM and was also converted into an ABPP probe for visualizing NOTUM in native biological systems. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Wnt | ||
Structure
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