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ABC99 Chemical Structure

ABC99

Data Sheet For research use only. Not for human use.
Cat. No. :BCP47152CAS No. :2331255-53-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2331255-53-7 Cat. No. BCP47152
Name ABC99
Synonyms ABC-99; ABC 99;
SMILES C1CN2C(CN1CC3=CC=C(C=C3)Cl)C(=O)N(C2=O)OC(=O)N4CCOC5=CC=CC=C54
Chemical Name
Formula C22H21ClN4O5 M. Wt 456.88
Purity 98% Storage Store at 4-8°C
Description ABC99 is a Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme, ABC99 inhibited NOTUM with an IC50 value of 13 nM and showed excellent selectivity across the serine hydrolase family, as initially assessed by gel-based ABPP of soluble and membrane proteomes from SW620 cells. ABC99 preserves Wnt-mediated cell signaling in the presence of NOTUM and was also converted into an ABPP probe for visualizing NOTUM in native biological systems.
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