LY294002
| CAS No. | 154447-36-6 | Cat. No. | BCP00195 |
| Name | LY294002 | ||
| Synonyms | NSC 697286; SF 1101; LY 294002; LY-294002; NSC-697286; SF-1101; NSC697286; SF1101; | ||
| Formula | C19H17NO3 | M. Wt | 307.34 |
| Description | LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
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Cerebroprotective Effects of Ginsenoside Rg1 on Rats
with Amyloid β-Protein Induced Alzheimer’s Disease
Publications Citing of Biochempartner's LY294002(CAS:154447-36-6) |
Structure
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