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LY294002 Chemical Structure

LY294002

Data Sheet For research use only. Not for human use.
Cat. No. :BCP00195CAS No. :154447-36-6Purity:98%
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  • Publications Citing of Biochempartner's LY294002
  • Chemical Properties&Biological Activity
CAS No. 154447-36-6 Cat. No. BCP00195
Name LY294002
Synonyms NSC 697286; SF 1101; LY 294002; LY-294002; NSC-697286; SF-1101; NSC697286; SF1101;
SMILES O=C1C=C(N2CCOCC2)OC3=C(C4=CC=CC=C4)C=CC=C13
Chemical Name
Formula C19H17NO3 M. Wt 307.34
Purity 98% Storage Store at 4-8°C
Description LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.
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