
LY294002

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CAS No. | 154447-36-6 | Cat. No. | BCP00195 |
Name | LY294002 | ||
Synonyms | NSC 697286; SF 1101; LY 294002; LY-294002; NSC-697286; SF-1101; NSC697286; SF1101; | ||
SMILES | |||
Chemical Name | |||
Formula | C19H17NO3 | M. Wt | 307.34 |
Purity | 98% | Storage | Store at 4-8°C |
Description | LY294002 inactivates Akt/PKB, consequently inhibiting cell proliferation and inducing apoptosis. LY294002 demonstrates a remarkable growth-inhibitory and apoptosis-inducing effect in these colon cancer cell lines, with decreased expression of phosphorylated Akt (Ser473). LY294002 induces marked nuclear pyknosis and diminished cytoplasmic volume in the tumor cells. Thus, LY294002 markedly inhibits ovarian cancer cell proliferation in vitro. LY294002 induces specific G1 arrest in cell growth, lead |
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