LY294002 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP00195CAS No. ：154447-36-6Purity：98%

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CAS No.	154447-36-6	Cat. No.	BCP00195
Name	LY294002
Synonyms	NSC 697286; SF 1101; LY 294002; LY-294002; NSC-697286; SF-1101; NSC697286; SF1101;
SMILES	O=C1C=C(N2CCOCC2)OC3=C(C4=CC=CC=C4)C=CC=C13
Chemical Name
Formula	C19H17NO3	M. Wt	307.34
Purity	98%	Storage	Store at 4-8°C
Description	LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.