盐酸阿夫唑嗪
| CAS号 | 81403-68-1 | 货号 | BCP02086 |
| 中文名 | 盐酸阿夫唑嗪 | ||
| 英文名 | Alfuzosin hydrochloride | ||
| 中文别名 | |||
| 英文别名 | Uroxatral; | ||
| 分子式 | C19H27N5O4.HCl | 分子量 | 425.91 |
| 生物活性 | Alfuzosin, a new quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder outlet resistance, bladder instability and symptoms associated with benign prostatic hyperplasia are reduced. A limited range of clinical studies have shown oral alfuzosin to be more effective than placebo (in studies of < or = 6 months duration), to have sustained effects on long term administration (< or = 30 months), and to be comparable with the alpha 1-adrenoceptor antagonist prazosin, in the symptomatic treatment of benign prostatic hyperplasia. Oral alfuzosin 7.5 to 10 mg/day in divided doses appears to be a promising first-line agent for symptomatic treatment of noncomplicated mild to moderate benign prostatic hyperplasia in patients with a high dynamic component t | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | Adrenergic Receptor | ||
结构式
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