Ingenol-3-angelate

CAS No.	75567-37-2	Cat. No.	BCP10402
Name	Ingenol-3-angelate
Synonyms	PEP005; PEP-005; PEP 005; Ingenol mebutate;3-ingenol angelate;Ingenol 3-angelate;
Formula	C25H34O6	M. Wt	430.54

Description	Ingenol mebutate, also known as ingenol-3-angelate, is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. Ingenol Mebutate was approved for the topical treatment of actinic keratosis. Ingenol mebutate has also been found to be useful for reactivating latent HIV virus in cells taken from individuals who have tested negative for signs of the disease following extended courses of anti-retroviral drugs, raising the possibility that this drug may be used to expose the last traces of virus, and thus potentially provide a permanent cure for HIV infection.
Pathways	TGF beta/Smad Epigenetics
Targets	PKC

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