AV-412 Tosylate
| CAS No. | 451493-31-5 | Cat. No. | BCP23783 |
| Name | AV-412 Tosylate | ||
| Synonyms | MP-412; MP 412; MP412; AV-412; AV 412; AV412; | ||
| Formula | C41H44ClFN6O7S2 | M. Wt | 851.41 |
| Description | AV-412, also known as MP-412, is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR HER2 | ||
Structure
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