Pifithrin-alpha, p-Nitro, Cyclic
| CAS No. | 60477-38-5 | Cat. No. | BCP25188 |
| Name | Pifithrin-alpha, p-Nitro, Cyclic | ||
| Synonyms | PFN-α;p-Nitro-CyclicPifithrin-alpha; | ||
| Formula | C15H13N3O2S | M. Wt | 299.35 |
| Description | Pifithrin-α, p-Nitro, Cyclic is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | p53 | ||
Structure
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