Pifithrin-alpha, p-Nitro, Cyclic New
Data Sheet
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| CAS No. | 60477-38-5 | Cat. No. | BCP25188 |
| Name | Pifithrin-alpha, p-Nitro, Cyclic | ||
| Synonyms | PFN-α;p-Nitro-CyclicPifithrin-alpha; | ||
| SMILES | C1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-] | ||
| Chemical Name | |||
| Formula | C15H13N3O2S | M. Wt | 299.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pifithrin-α, p-Nitro, Cyclic is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue. | ||
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