LDN-193189 2HCl
| CAS No. | 1435934-00-1 | Cat. No. | BCP20431 |
| Name | LDN-193189 2HCl | ||
| Synonyms | LDN193189; LDN 193189; LDN-193189; | ||
| Formula | C25H22N6 . 2ClH | M. Wt | 479.41 |
| Description | LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively. LDN193189 also inhibits BMP type I receptors ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase TGF beta/Smad | ||
| Targets | BMP/TGF beta Receptor ALK | ||
Structure
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